Rowe Researcher: Investigating Propargyl-Linked Antifolates

Summer 2012-Spring 2014: Investigating Propargyl-Linked Antifolates in Inhibiting Bacterial and Fungal Dihydrofolate Reductase

By Joshua Andrade, Dr. Amy Anderson’s Lab, and Dr. Dennis Wright’s Lab

Antimicrobial agents have been invaluable in reducing illness and death associated with bacterial infection. However, over time, bacteria have evolved resistance to all major drug classes as a result of selective pressure. The advancement of new drug compounds is therefore vital.  The Anderson-Wright Lab has focused on developing potent and selective inhibitors of dihydrofolate reductase (DHFR), an enzyme key in cell proliferation and survival, in several pathogenic species.  The lab has found that a set of compounds, known as propargyl-linked antifolates, are DHFR inhibitors that are both biologically effective and have strong pharmacokinetic properties. Continue reading

2010 Rowe Scholar: Joshua Andrade

Joshua Andrade
Joshua Andrade

Joshua Andrade is from Stratford, Connecticut. He is a graduate of Stratford High School where he was a part of both the lacrosse and dance teams. He will be majoring in psychology at UConn. His previous experiences in the health fields include working with How Youth Positively Entertain (HYPE) which explores the effects of drugs on the body, and he has assisted with Red Cross blood drives.