Research

Rowe Researcher: Osteoblast Cell Culture

Posted on by

Summer 2008: Optimizing Osteoblast Cell Culture for the Study of Dlx Gene Function

By Sean Ghassem-Zadeh

With the high volume of research involving in vitro studies and the need to optimize specific types of cell cultures, multiple companies have produced various Fetal Bovine Serum (FBS) products that can aid cell culture processes. With numerous companies producing multiple lots of FBS, which are obtained from an isolated population of fetal calves, a further investigation is needed to determine the best product for a desired cell culture (in this case calvaria and bone marrow cultures). Continue reading →

Rowe Researcher: Autoimmune Uveitis

Posted on by
Philip Gorecki conducting research.
Philip Gorecki conducting research.

Summer 2008: Autoimmunity to Interphotoreceptor Retinoid Binding Protein

By Philip J. Gorecki, Robert E. Cone, Ph.D., and Rajwardhan Yadav, M.D./Ph.D. Dept. of Immunology & Connecticut Lions’ Vascular Vision Center University of Connecticut Health Center, Farmington, Conn.

Autoimmune uveitis is a condition in which the immune response is directed against retinal antigens. Interphotoreceptor retinoid binding protein (IRBP) is an immunodominant antigen that stimulates T and B lymphocytes. Our aim was to characterize IRBP specific immune responses using a mouse model. Continue reading →

Rowe Researcher: Angelmans syndrome

Posted on by
Devorah Donnell conducting research.
Devorah Donnell conducting research.

Summer 2007: A cause of Angelmans syndrome, a form of mental retardation, in terms of Ubiquitin Protein Ligase 3A (UBE3A) expression’s impact on resistance to genotoxic stressors

By Devorah Donnell

Through the UConn Medical School’s Summer Research Fellowship Program, I conducted stem cell research in the summer of 2007 in Dr. Lalande’s laboratory in the department of Genetics and Developmental Biology at the UConn Health Center. I studied a cause of Angelmans syndrome, a form of mental retardation, in terms of Ubiquitin Protein Ligase 3A (UBE3A) expression’s impact on resistance to genotoxic stressors. Continue reading →