Summer 2008: Studying the Effects of a Potential New Chemotherapeutic Agent, SAM, on a Breast Cancer Cell Line and on a Yeast Model for Cancer
By Luke Monteagudo
During my summer fellowship, I worked four days a week doing basic science research on the effect of a potential new chemotherapeutic drug, SAM, on a breast cancer cell line and on a yeast model for cancer. Continue reading
Summer 2008: Identification of Candidate Acoustic Cues for Sound Localization
By Rishi Kothari
Sound localization is an important ability for all animals for a variety of reasons, including avoiding predation and finding food. The localization of sound in animals, as well as humans, has been investigated extensively with respect to varying azimuth, but substantially less study has been done on the effects of changing the distance or elevation of the sound source. Continue reading
Summer 2008: Optimizing Osteoblast Cell Culture for the Study of Dlx Gene Function
By Sean Ghassem-Zadeh
With the high volume of research involving in vitro studies and the need to optimize specific types of cell cultures, multiple companies have produced various Fetal Bovine Serum (FBS) products that can aid cell culture processes. With numerous companies producing multiple lots of FBS, which are obtained from an isolated population of fetal calves, a further investigation is needed to determine the best product for a desired cell culture (in this case calvaria and bone marrow cultures). Continue reading
Summer 2008: Autoimmunity to Interphotoreceptor Retinoid Binding Protein
By Philip J. Gorecki, Robert E. Cone, Ph.D., and Rajwardhan Yadav, M.D./Ph.D. Dept. of Immunology & Connecticut Lions’ Vascular Vision Center University of Connecticut Health Center, Farmington, Conn.
Autoimmune uveitis is a condition in which the immune response is directed against retinal antigens. Interphotoreceptor retinoid binding protein (IRBP) is an immunodominant antigen that stimulates T and B lymphocytes. Our aim was to characterize IRBP specific immune responses using a mouse model. Continue reading
Summer 2007: A cause of Angelmans syndrome, a form of mental retardation, in terms of Ubiquitin Protein Ligase 3A (UBE3A) expression’s impact on resistance to genotoxic stressors
By Devorah Donnell
Through the UConn Medical School’s Summer Research Fellowship Program, I conducted stem cell research in the summer of 2007 in Dr. Lalande’s laboratory in the department of Genetics and Developmental Biology at the UConn Health Center. I studied a cause of Angelmans syndrome, a form of mental retardation, in terms of Ubiquitin Protein Ligase 3A (UBE3A) expression’s impact on resistance to genotoxic stressors. Continue reading